منابع مشابه
“Orphan” Retrogenes in the Human Genome
Gene duplicates generated via retroposition were long thought to be pseudogenized and consequently decayed. However, a significant number of these genes escaped their evolutionary destiny and evolved into functional genes. Despite multiple studies, the number of functional retrogenes in human and other genomes remains unclear. We performed a comparative analysis of human, chicken, and worm geno...
متن کاملThe human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination.
L1 retrotransposons play an important role in mammalian genome shaping. In particular, they can transduce their 3'-flanking regions to new genomic loci or produce pseudogenes or retrotranscripts through reverse transcription of different kinds of cellular RNAs. Recently, we found in the human genome an unusual family of chimeric retrotranscripts composed of full-sized copies of U6 small nuclear...
متن کاملGenome-wide analyses of retrogenes derived from the human box H/ACA snoRNAs
The family of box H/ACA snoRNA is an abundant class of non-protein-coding RNAs, which play important roles in the post-transcriptional modification of rRNAs and snRNAs. Here we report the characterization in the human genome of 202 sequences derived from box H/ACA snoRNAs. Most of them were retrogenes formed using the L1 integration machinery. About 96% of the box H/ACA RNA-related sequences ar...
متن کاملExtensive structural renovation of retrogenes in the evolution of the Populus genome.
Retroposition, as an important copy mechanism for generating new genes, was believed to play a negligible role in plants. As a representative dicot, the genomic sequences of Populus (poplar; Populus trichocarpa) provide an opportunity to investigate this issue. We identified 106 retrogenes and found the majority (89%) of them are associated with functional signatures in sequence evolution, tran...
متن کاملidentification and discovery of novel micrornas in the human genome
although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. rather, they are considered as non-coding rnas. micrornas (mirnas) are very short non-coding rnas approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2012
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/mss235